Systemic sclerosis is an intractable disease characterized by collagen deposition and fibrosis of skin and organs. Supportive treatment to relieve symptom is a sole remedy.
We found a compound HPH-15 that suppresses the collagen production in fibroblast. HPH-15 ameliorated the skin thickness of systemic sclerosis model mice.
HPH-15 is currently at pre-clinical study. We are collaborating with dermatology department of Kumamoto University Hospital.
Owing to the recent anti-HIV drugs symptoms of AIDS became amenable to control. However, since HIV latently survives in the patient's body, the disease recurs by interruption of drugs.
We developed a novel drug that encloses the HIV inside the host cells and kills HIV together with the host cells. This would lead to the eradication of AIDS.
Cerebral infarction is a blockade of brain arteries resulting in ischemia and cerebral cell death. This process is suppressed by neuroprotectants.
We developed a new compound CNN that scavenges toxic substance HNE produced by cerebral ischemia. CNN showed effect in Mongolian Gerbil ischemia model, as demonstrated by a collaboration with department of neurosurgery, Kurume University.
Phytic acid shows a range of biological activities, i.e., anti-cancer, anti-diabetic, immuno-potentiating, kidney stone-protecting, cholesterol-lowering, and coronay artery disease-preventing effects. However, due to low cell permeability, there has been limitation in cellular study for drug development.
We developed a cell-permeable prodrug that release the parent phytic acid in cells, promising for life science study as well as drug development.