AIDS eradication​

 AIDS used to be a fatal disease. Owing to the development of various anti-HIV drugs, progress of AID became amenable to control by the multi drug therapy.

 However, as HIV persists in the patients body, the disease recurs if the drug administration was disturbed. We try to develop a novel remedy to quench HIV from the patients body to complete cure.

 

 Our developed a compound named L-HIPPO.

  ・L-HIPPO encloses HIV inside the host cells. HIV can not go out of the host cell.

  ・The host cells enclosing HIV dies. HIV inside dies altogether. 

 

 This is the cellular experiment at present. We wish to quench HIV in patients body to achieve the complete cure with no need of drug any more. We wish to clear HIV in the body of ALL patients in the world.

L-HIPPO Eng.png

 We have synthesized L-HIPPO and its mirror image D-HIPPO. L-HIPPO suppressed the budding of HIV more efficiently. Further L-HIPPO induced apoptosis (cell death) of the treated cells. We named this process "Lock-in and apoptosis".

Lock-in.png
Apoptosis.png